abstract：:Modified forms of tau proteins are major components of the paired helical filaments (PHFs) present in Alzheimer brains. In this study, tau from cytosolic samples obtained from normal and Alzheimer disease brains were fractionated by iron-chelated affinity chromatography (ICAC) to discriminate between isoforms phosphor...

journal_title：Neurobiology of aging

authors： Ledesma MD,Avila J,Correas I

更新日期：1995-07-01 00:00:00

abstract：:The effect of normal aging on the volume of the hippocampus and temporal cortex was assessed cross-sectionally with quantitative Magnetic Resonance Imaging (MRI) in 72 healthy men, spanning 5 decades of the adult age range (21 to 70 years). Neither the hippocampal nor cortical white matter volumes were significantly c...

journal_title：Neurobiology of aging

authors： Sullivan EV,Marsh L,Mathalon DH,Lim KO,Pfefferbaum A

更新日期：1995-07-01 00:00:00

abstract：:The observation that neurons containing neurofibrillary tangles are usually adjacent to neurons free of any morphological indication of disease, suggests the hypothesis that it is NFT-bearing neurons that are primarily responsible for the loss of function in AD. Quantitative Golgi postmortem studies from our laborator...

journal_title：Neurobiology of aging

authors： Callahan LM,Coleman PD

更新日期：1995-05-01 00:00:00

abstract：:In Alzheimer's disease, there is a major redistribution of the tau protein pool from soluble to PHF-bound forms. PHF-bound tau can be distinguished from normal tau by acid reversible occlusion of a generic tau epitope in the tandem repeat region and characteristic sedimentation in the if-II protocol developed in this ...

journal_title：Neurobiology of aging

authors： Wischik CM,Edwards PC,Lai RY,Gertz HN,Xuereb JH,Paykel ES,Brayne C,Huppert FA,Mukaetova-Ladinska EB,Mena R

更新日期：1995-05-01 00:00:00

abstract：:Tyrosine hydroxylase (TH) mRNA, immunoreactivity, and activity were examined as a reflection of dopamine expression in juxtaglomerular neurons intrinsic to the olfactory bulbs of young (6-month-old), middle aged (18-month-old), and aged (25- to 29-month-old) rats and mice. TH expression was maintained at levels observ...

journal_title：Neurobiology of aging

authors： Baker H,Franzen L,Stone D,Cho JY,Margolis FL

更新日期：1995-03-01 00:00:00

abstract：:The total number of immunocytochemically identified vasopressin (AVP) cells was determined morphometrically in the paraventricular (PVN) and dorsolateral part of the supraoptic nucleus (dl-SON) of the human hypothalamus in 30 subjects ranging in age from 15 to 97 years, including 10 Alzheimer's disease (AD) patients. ...

journal_title：Neurobiology of aging

authors： Van der Woude PF,Goudsmit E,Wierda M,Purba JS,Hofman MA,Bogte H,Swaab DF

更新日期：1995-01-01 00:00:00

abstract：:The relationship between hematological variables and the ability to perform behaviorally in two learning tests was evaluated in male F344 rats aged 22-24 months. Rats were screened for ability to meet criterion for learning one-way active avoidance in a straight runway task. Rats failing to meet criterion were given n...

journal_title：Neurobiology of aging

authors： Spangler EL,Waggie KS,Rea W,Roberts D,Hengemihle J,Danon D,Ingram DK

更新日期：1995-01-01 00:00:00

abstract：:Alzheimer's disease (AD) has been suggested to be a systemic disease, and signal transduction abnormalities have been reported in non-neuronal AD cells. We have previously quantified the protein kinase C (PKC) subtypes in AD and control brains using a two-site enzyme immunoassay (EIA), and have shown that type II PKC ...

journal_title：Neurobiology of aging

authors： Matsushima H,Shimohama S,Tanaka S,Taniguchi T,Hagiwara M,Hidaka H,Kimura J

更新日期：1994-11-01 00:00:00

abstract：:Threshold and suprathreshold sensitivities to 13 bitter compounds were determined for 16 young adults (mean age = 27.4 years) and 18 elderly persons (mean age = 81.3 years). Half of the subjects in each age group were tasters of the bitter compound phenylthiocarbamide (PTC) and half were nontasters. Both detection and...

journal_title：Neurobiology of aging

authors： Schiffman SS,Gatlin LA,Frey AE,Heiman SA,Stagner WC,Cooper DC

更新日期：1994-11-01 00:00:00

abstract：:In this study, the Purkinje neurons and granule neurons in the cerebellar cortex were studied in male Fischer 344 rats at 3, 9, 18, and 27 months of age. The numbers of Purkinje cells (PC) and granule cells (GC) in folia IV, VII, and X of the vermis were quantitated with the disector stereological technique. The numbe...

journal_title：Neurobiology of aging

authors： Dlugos CA,Pentney RJ

更新日期：1994-07-01 00:00:00

abstract：:Neuropeptide Y (NPY) has been implicated in the control of reproductive and cardiovascular function. We observed an age-related decrease in the number of males copulating to ejaculation and a moderate systolic hypertension in middle-aged (16- to 17-month-old) rats. NPY content was examined in microdissected brain nucl...

journal_title：Neurobiology of aging

authors： Clark JT

更新日期：1994-03-01 00:00:00

abstract：:The excitatory amino acids (EAAs) L-aspartate and L-glutamate constitute the major neurotransmitters in the mammalian brain. This study established the influence of aging and oxidative stress on the release and uptake of EAAs. The high affinity uptake of D-[3H]aspartate in synaptosomal fractions of the neostriatum, hi...

journal_title：Neurobiology of aging

authors： Palmer AM,Robichaud PJ,Reiter CT

更新日期：1994-01-01 00:00:00

abstract：:The etiology of Alzheimer's disease is still unknown. Because the disease is specific for human brain, a rational search for early diagnosis or prevention is very difficult. This calls for the development of cellular models that mimick the degeneration of neurons in AD. The brains of AD patients contain markers whose ...

journal_title：Neurobiology of aging

authors： Mandelkow EM,Mandelkow E

更新日期：1994-01-01 00:00:00

abstract：:We obtained serum samples and measured alpha 1-antichymotrypsin (ACT) levels in 36 pairs of consecutive probable Alzheimer's disease (AD) patients and age- and sex-matched, cognitively intact control subjects. Serum ACT was measured by radial immunodiffusion. Unique to this study, we found that ACT levels rose signifi...

journal_title：Neurobiology of aging

authors： Hinds TR,Kukull WA,Van Belle G,Schellenberg GD,Villacres EC,Larson EB

更新日期：1994-01-01 00:00:00

abstract：:It has been suggested that the A beta fragment of the amyloid precursor protein in Alzheimer's disease arises from internal translation initiation at Met596 (1). Here we use the recently described in vitro model of A beta production and secretion (2) to examine this hypothesis. We show that A beta is no longer detecta...

journal_title：Neurobiology of aging

authors： Citron M,Haass C,Selkoe DJ

更新日期：1993-11-01 00:00:00

abstract：:Aging is associated with alterations in different systems that govern neuronal calcium homeostasis. This study was designed to determine whether any of these alterations may contribute to the decline in spatial working memory that is observed in old rats. Several parameters [initial (5 s) and steady state (15 min) 45C...

journal_title：Neurobiology of aging

authors： Huidobro A,Blanco P,Villalba M,Gómez-Puertas P,Villa A,Pereira R,Bogónez E,Martínez-Serrano A,Aparicio JJ,Satrústegui J

更新日期：1993-09-01 00:00:00

abstract：:New highly-accurate stereological methods for estimating the total numbers of neurons in brain structures have been used to test for age-related neuron loss in the human hippocampal formation. Across the age range of 13 to 85 years, there was a substantial loss of neurons in the subiculum (52%) and in the hilus of the...

journal_title：Neurobiology of aging

authors： West MJ

更新日期：1993-07-01 00:00:00

abstract：:The 3-dimensional (3-D) distribution of cholinergic neurons located throughout the extent of the entire basal forebrain of young (4-5 months old) and aged (24-25 months old) Fischer-344 rats was examined using choline acetyltransferase immunocytochemistry (ChAT-IR). The number and 3-D position of ChAT-IR neurons spann...

journal_title：Neurobiology of aging

authors： Smith ML,Deadwyler SA,Booze RM

更新日期：1993-07-01 00:00:00

abstract：:To determine if the membrane disordering effect of ethanol on cerebral microvessels is altered with age, the steady state fluorescence polarization (P) of diphenyl-hexatriene (DPH) and 1-(4-trimethylammoniumphenyl)-6-phenyl-1,3,5-hexatriene (TMA-DPH) which report on the membrane core and surface region, respectively, ...

journal_title：Neurobiology of aging

authors： Mooradian AD,Smith TL

更新日期：1993-05-01 00:00:00

abstract：:Although senile plaques represent a consistent neuropathological feature in Alzheimer's brains, it is not known what role plaques play in the etiology of the disease. Both growth-promoting and growth-inhibiting influences have been postulated. One of the major components in plaques, beta-amyloid, has been shown to aff...

journal_title：Neurobiology of aging

authors： Carpenter MK,Crutcher KA,Kater SB

更新日期：1993-05-01 00:00:00

abstract：:We previously established a single-neuron culture system to analyze the primary effects of neurotrophic factors and reported that NGF promoted neurite extension in young adult (4- to 6-month-old) rat dorsal root ganglion (DRG) neurons by promoting neurite arborization. In this study, we demonstrated that the effects o...

journal_title：Neurobiology of aging

authors： Itoh T,Sobue G,Yasuda T,Kimata K,Mitsuma T,Takahashi A

更新日期：1993-03-01 00:00:00

abstract：:Cortisol and ACTH exhibit circadian rhythmicity, peaking in the early morning. These peaks are associated with increased activity and alertness. We sought to determine whether self-reported daily rhythms predict outcome of a.m. and p.m. CRH challenge in elderly subjects. We surveyed 96 elderly subjects to determine da...

journal_title：Neurobiology of aging

authors： Blazer DG,Malmrose LC,Wallsten SM,Nemeroff CB,Reed DA,Ritchie JC,Tyrey ME

更新日期：1993-01-01 00:00:00

abstract：:Aged rats were chronically administered acetyl-L-carnitine (AC) for 10 months. During this period they were tested on learning and sensorimotor tasks and were then subsequently tested electrophysiologically to assess induction and decay rates of long-term synaptic enhancement (LTE) in the hippocampus. Four groups were...

journal_title：Neurobiology of aging

authors： Davis S,Markowska AL,Wenk GL,Barnes CA

更新日期：1993-01-01 00:00:00

abstract：:Changes in regional cerebral blood flow (rCBF) associated with a face-matching task were examined using positron emission tomography (PET) and H2(15)O in 7 patients with mild-moderate dementia of the Alzheimer type (DAT) and in 8 healthy age-matched controls. rCBF was normalized to whole brain flow and pixel-by-pixel ...

journal_title：Neurobiology of aging

authors： Grady CL,Haxby JV,Horwitz B,Gillette J,Salerno JA,Gonzalez-Aviles A,Carson RE,Herscovitch P,Schapiro MB,Rapoport SI

更新日期：1993-01-01 00:00:00

abstract：:Significant advances in the technology for the isolation of peptides and small proteins have permitted their identification as biologic markers and enhanced the study of the posttranslational life of proteins. The protocol described here examined large numbers of tissue-derived peptides and small proteins, extracted i...

journal_title：Neurobiology of aging

authors： Slemmon JR,Flood DG

更新日期：1992-11-01 00:00:00

abstract：:This study examined the progression of sleep-disordered breathing (SDB) over 1 year in two samples of elderly subjects: 45 healthy controls (20 men; 25 women mean age 74.8 years) and 27 recently spousally bereaved elders (9 men; 18 women, mean age 69.7 years). Although controls and bereaved subjects did not differ in ...

journal_title：Neurobiology of aging

authors： Hoch CC,Reynolds CF 3rd,Buysse DJ,Machen M,Schlernitzauer M,Hall F,Kupfer DJ

更新日期：1992-11-01 00:00:00

abstract：:beta A4 peptide (beta AP) accumulates in amyloid plaques of Alzheimer's disease and may contribute to neuronal degeneration. Conflicting observations have been reported regarding the direct in vitro and in vivo neurotoxicity of beta AP. We have assessed in vitro beta AP toxicity in high density primary rat hippocampal...

journal_title：Neurobiology of aging

authors： May PC,Gitter BD,Waters DC,Simmons LK,Becker GW,Small JS,Robison PM

更新日期：1992-09-01 00:00:00

abstract：:Cell culture systems for evaluating the biological effects of the beta-amyloid protein are potentially important tools in the study of the pathogenesis of Alzheimer's disease. In this report, methodological considerations in the assessment of beta-amyloid neurotoxicity are discussed. Chronic incubation of beta 1-40 in...

journal_title：Neurobiology of aging

authors： Busciglio J,Lorenzo A,Yankner BA

更新日期：1992-09-01 00:00:00

abstract：:Brains were examined from 22 patients with Alzheimer's disease (AD) (mean age 80.5, S.D. 11.5) and were compared with brains from 20 nondiseased subjects (mean age 81.1, S.D. 10.2). Intraneuronal lipopigment in all layers of a region of the superior frontal cortex was identified by fluorescence microscopy. The areas e...

journal_title：Neurobiology of aging

authors： Dowson JH,Mountjoy CQ,Cairns MR,Wilton-Cox H

更新日期：1992-07-01 00:00:00

abstract：:The hippocampal perforant pathway originates in the entorhinal cortex (ERC) and terminates in the outer molecular layer of the dentate gyrus (DG). To compare the effects of normal aging and Alzheimer's disease (AD) on the elements of the perforant pathway, we compared relative perikaryal numbers (determined by countin...

journal_title：Neurobiology of aging

authors： Lippa CF,Hamos JE,Pulaski-Salo D,DeGennaro LJ,Drachman DA

更新日期：1992-05-01 00:00:00

abstract：:Open field behavior and age-related changes in anterior pituitary corticotropin-releasing hormone (CRH) receptors, as well as plasma ACTH levels, were measured in two inbred rat strains. The strains utilized were Wistar Kyoto (WKY) and Brown-Norway (BN), the former characterized by shorter life-span and hyper-reactivi...

journal_title：Neurobiology of aging

authors： Tizabi Y,Aguilera G,Gilad GM

更新日期：1992-03-01 00:00:00

abstract：:The present study was designed to examine the effects of the aging process on the response of motoneurons to axotomy. Accordingly, in aged cats using intracellular recording techniques, the electrophysiological properties of axotomized lumbar spinal cord motoneurons were compared with those of control (nonaxotomized) ...

journal_title：Neurobiology of aging

authors： Yamuy J,Englehardt JK,Morales FR,Chase MH

更新日期：1992-03-01 00:00:00

abstract：:The monoamine metabolites homovanillic acid (HVA), 5-hydroxy-indoleacetic acid (5-HIAA) and 4-hydroxy-3-methoxy-phenylglycol (HMPG) were determined in lumbar cerebrospinal fluid (CSF) of 123 patients with Alzheimer's disease (AD) and 57 healthy controls. Despite CSF sampling under strictly standardized conditions, a w...

journal_title：Neurobiology of aging

authors： Blennow K,Wallin A,Gottfries CG,Lekman A,Karlsson I,Skoog I,Svennerholm L

更新日期：1992-01-01 00:00:00

abstract：:Chronic treatment (21 days) with phosphatidylserine (BC-PS) partially restored the reduced density of muscarinic cholinergic receptors in several regions of the aged (18 months) mouse brain. The effect was similar whether 3H-QNB or 3H-NMS was used as radioligand. The affinity of both radioligands was not altered by BC...

journal_title：Neurobiology of aging

authors： Gelbmann CM,Müller WE

更新日期：1992-01-01 00:00:00

abstract：:The available published guidelines for the housing of rodents are reviewed, and assessments are made with regard to whether the data on which these guidelines are based appear to be sound. Ambient air temperature, relative humidity, lighting levels and photoperiods, sound levels, cage sizes, and ventilation rates are ...

journal_title：Neurobiology of aging

authors： Clough G

更新日期：1991-11-01 00:00:00

abstract：:In the present study, the effects of long-term dietary restriction (60% of the calories in the ad lib diet, beginning at 16 weeks of age) on quantitative morphometric measures and histopathologic indications of aging have been investigated in the retina of Fischer 344 male rats. The animals were maintained by the NIA ...

journal_title：Neurobiology of aging

authors： O'Steen WK,Landfield PW

更新日期：1991-09-01 00:00:00

abstract：:Four biopsies of the brain cortex of patients with Alzheimer's disease were used for ultrastructural studies. Three-dimensional reconstruction and morphometric studies of three classical plaques were carried out to determine the distribution of the astrocytes and their processes, and spatial relationships between astr...

journal_title：Neurobiology of aging

authors： Wisniewski HM,Wegiel J

更新日期：1991-09-01 00:00:00

abstract：:Striatal dopamine (DA) and metabolite (DOPAC) levels in 8-, 21-, 52- and 104-week-old C57BL mice were compared with those in 11-week-old mice, 20 days after 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) treatment. DA and DOPAC concentrations expressed relative to striatal wet weight did not change with age. In c...

journal_title：Neurobiology of aging

authors： Greenwood CE,Tatton WG,Seniuk NA,Biddle FG

更新日期：1991-09-01 00:00:00

abstract：:A common analogy to aging is that of a boulder being worn down to rubble by the unremitting onslaught of time. In contrast, Swaab's "use it or lose it" concept is important because it emphasizes some positive consequences of experience. For example, early exposure to complex experience may offer some protection from "...

journal_title：Neurobiology of aging

authors： Black JE,Isaacs KR,Greenough WT

更新日期：1991-07-01 00:00:00

abstract：:Subcortical structural changes have been reported to occur in some elderly subjects with late age onset depression. Given the association between diseases affecting subcortical structures and affective disorders, this suggests that these structural changes may be involved in the etiology of late age onset depression i...

journal_title：Neurobiology of aging

authors： Figiel GS,Krishnan KR,Doraiswamy PM,Rao VP,Nemeroff CB,Boyko OB

更新日期：1991-05-01 00:00:00